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Effect of A3309 and placebo on weekly stool consistency, straining, and bloating. Changes in stool consistency (a), straining (b), and bloating (c) over the treatment period. Significance values shown are for the overall change from baseline between A3309 and placebo. ***P<0.001, *P<0.05. BSFS, Bristol Stool Form Scale (7-graded scale, see text for explanations); ITT, intention to treat.
