Table 1.

Evaluation of Primary Hypothyroidism Algorithm at the Five eMERGE Sites

Site	Primary Phenotype	Total Genotyped Subjects	Primary Hypothyroidism
			Cases	Controls	Case PPV (%)	Control PPV (%)
Group Health	dementia	2532	397	1,160	98	100
Marshfield	cataracts	4113	514	1,187	91	100
Mayo Clinic	peripheral arterial disease	3043	233	1,884	82	96
Northwestern	type 2 diabetes	1217	92	470	98	100
Vanderbilt	normal cardiac conduction	2712	81	352	98	100
All sites		13,617	1317	5053	92.4a	98.5a

Genotype counts represent all subjects who were found by the hypothyroidism algorithms at each site and who were genotyped. Counts are limited to those classified as “white” in the electronic medical record of each site. PPV = positive predictive value.

^aAverage weighted for number of samples contributed to the total.