Table 4.
Association of SNPs near FOXE1 with Hypothyroidism in Each eMERGE Site and Replication Set
| SNP |
eMERGE GWAS Sites |
Replication Set |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
All Sites (n = 1317/5053)a |
GHC (n = 233/1884) |
Marshfield (n = 514/1187) |
Mayo (n = 233/1884) |
Northwestern (n = 92/470) |
Vanderbilt (n = 81/352) |
n = 263/1616 |
||||||||
| Odds Ratio (95% CI) | p Value | Odds ratio (95% CI) | p Value | Odds Ratio (95% CI) | p Value | Odds Ratio (95% CI) | p Value | Odds Ratio (95% CI) | P-Value | Odds Ratio (95% CI) | p Value | Odds Ratio (95% CI) | p Value | |
| rs7850258 | 0.74 (0.67–0.82) | 3.93 × 10−9 | 0.81 (0.68–0.96) | 0.02 | 0.74 (0.62–0.88) | 6.24 × 10−4 | 0.78 (0.63–0.97) | 0.02 | 0.64 (0.44–0.92) | 0.02 | 0.60 (0.40–0.91) | 0.02 | 0.60 (0.48–0.74) | 5.7 × 10−6 |
| rs965513 | 0.74 (0.67–.082) | 4.1510−9 | 0.81 (0.68–0.96) | 0.02 | 0.74 (0.62–0.88) | 6.24 × 10−4 | 0.77 (0.62–0.96) | 0.02 | 0.64 (0.44–0.92) | 0.02 | 0.60 (0.40–0.91) | 0.02 | 0.59 (0.47–0.74) | 5.8 × 10−6 |
| rs925489 | 0.74 (0.67–.082) | 4.64 × 10−9 | 0.81 (0.67–0.95) | 0.01 | 0.75 (0.63–0.89) | 8.71 × 10−4 | 0.78 (0.62–0.96) | 0.02 | 0.64 (0.44–0.92) | 0.02 | 0.60 (0.40–0.91) | 0.02 | 0.59 (0.46–0.74) | 1.1 × 10−5 |
| rs10759944 | 0.75 (0.68–.083) | 8.13 × 10−9 | 0.81 (0.68–0.97) | 0.02 | 0.75 (0.63–0.89) | 9.11 × 10−4 | 0.78 (0.63–0.97) | 0.02 | 0.64 (0.44–0.92) | 0.02 | 0.60 (0.40–0.91) | 0.02 | 0.60 (0.47–0.75) | 7.6 × 10−6 |
a
Counts represent number of cases/number of controls.