Figure 6.

Recovery from prolonged inactivation and lidocaine inhibition for I1461T channels. (A) Recovery of control (n = 4) and lidocaine-treated (n = 3) I1461T channels from a −100 mV pre-pulse. (B) Recovery profile of control (n = 4) and lidocaine-treated (n = 3) I1461T channels from a −50 mV pre-pulse. (C) Recovery profile of control (n = 4) and lidocaine-treated (n = 3) I1461T channels from a 0 mV pre-pulse. Insets: representative traces showing the magnitude of current recovered in the absence and presence of lidocaine (1 mM) for the specified pre-pulse voltage. Under all conditions, the recovery profile was fit with a second-order exponential growth equation. All fits had R² >0.90. Note, the data in (B) and (C) are the I1461T data from Figure 5 combined to better illustrate the effect of lidocaine on I1461T channel recovery.