Figure 8.

Upper GI transit in vivo in wild-type (WT), single and double peptide null mice following vehicle (control) or Y₁ or Y₂ receptor antagonists. Transit was increased significantly in PYY^−/− compared with WT transit rates (Student's unpaired t-test; *P≤ 0.05). The effects of Y₁ (BIBO3304, 0.4 mM·100 µL⁻¹, i.p.) or Y₂ (BIIE0246, 60 µg·100 µL⁻¹, i.p.) receptor antagonists on transit are shown for each genotype. There were no statistical differences between antagonist-treated transit rates and controls in WT, NPY^−/− or PYY^−/− mice. However, the inhibitory effects of both antagonists in PYY^−/− were significantly different from the slight prokinetic effects of both antagonists in WT controls (two-way anova, no asterisk shown). Each bar is the mean + SEM from number of assays in parenthesis.