Figure 5.

Lack of rebound food intake in DIO mice after cessation of daily s.c. injection with CNTF_Ax15. DIO mice (n = 7; starting BW ≈50 g) were treated for 3 (A₁ and B₁) or 7 days (A₂ and B₂) with vehicle (V) or CNTF_Ax15 (C, 0.1, 0.3 mg/kg/day), or were pair-fed to the food intake of CNTF_Ax15-treated mice (P) after which all treatment was stopped and all animals were returned to ad lib feeding. The 24-h food intake (A₁ and A₂) and change in body weight (percentage from day 0; B₁ and B₂) was measured throughout both studies. The overeating and rapid return to prerestriction body weight seen after returning pair-fed mice to ad lib feeding was not seen after cessation of treatment with CNTF_Ax15.