Figure 7.

Left ventricular hypertrophy in 5/6 NX rats and the effect of VS-105. Sham and 5/6 NX rats were treated with vehicle or VS-105 at the doses indicated, as described in Figure 3. (A) Heart was collected and weighed. Left ventricle (LV) was then dissected and weighed (n = 7–10 per group). Heart LV weight (LVW) was first normalized by body weight (BW) and then expressed as % of control (Sham). (B) The diameter of cardiomyocytes was determined as described in Methods. Data were obtained from 30 cells randomly selected from 10 microscopic fields across different rats in each treatment group and expressed as % of control (Sham). Group means ± SEM are presented. One-way anova Dunnett's test with 95% confidence intervals of difference was performed for statistical comparisons. ##P < 0.01, ###P < 0.001 versus Sham; **P < 0.01, ***P < 0.001 versus NX-vehicle.