Figure 8.

Cardiomyocyte morphology in 5/6 NX rats and the effect of VS-105. Sham rats were treated with vehicle and 5/6 NX rats were treated with vehicle or VS-105 at the indicated doses as described in Figure 3. The left ventricular tissue sections were prepared and stained with haematoxylin-eosin as described in Methods. Randomly selected areas under 200 × magnification were examined. Pictures shown are representative of 10 fields per section per rat, four rats per treatment group. (A) Sham; (B) 5/6 NX-vehicle; (C) 5/6 NX treated with VS-105 at 0.01 µg·kg⁻¹; (D) 5/6 NX treated with VS-105 at 0.16 µg·kg⁻¹.