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. 2011 Sep;164(2b):551–560. doi: 10.1111/j.1476-5381.2011.01473.x

Figure 9.

Figure 9

Left ventricle fibrosis in 5/6 NX rats and the effect of VS-105. The Sham rats were treated with vehicle and 5/6 NX rats were treated with vehicle or VS-105 at the indicated doses as described in Figure 5. The left ventricular tissue sections were prepared and stained with Masson trichrome as described in Methods. Randomly selected areas under 200 × magnification were examined. Pictures shown are representative of 10 fields per section per rat, four rats per treatment group. (A) Sham; (B) 5/6 NX-vehicle; (C) 5/6 NX treated with VS-105 at 0.01 µg·kg−1; (D) 5/6 NX treated with VS-105 at 0.5 µg·kg−1. (E) Quantitative determination of tissue collagen abundance; group means ± SEM are presented. One-way anova Dunnett's test with 95% confidence intervals of difference was performed for statistical comparisons. ###P < 0.001 versus Sham; ***P < 0.001 versus NX-vehicle.