Table 1.

Effects of VS-105 oral dosing on physiological parameters in Sham versus 5/6 nephrectomized rats

	Sham		5/6 NX-vehicle		5/6 NX-VS-105 (0.01 µg·kg−1)		5/6 NX-VS-105 (0.5 µg·kg−1)
Parameters	Day 0	Day 13	Day 0	Day 13	Day 0	Day 13	Day 0	Day 13
Creatinine (mg·dL−1)	0.45 ± 0.02	0.51 ± 0.03	1.01 ± 0.06***	1.12 ± 0.09***	0.87 ± 0.05***	0.93 ± 0.08***	0.83 ± 0.03***	0.81 ± 0.04***
BUN (mg·dL−1)	13.3 ± 1.2	14.1 ± 0.8	44.3 ± 3.6***	45.3 ± 5.0***	41.2 ± 4.7***	39.0 ± 3.9***	37.5 ± 2.8***	34.5 ± 3.0***
Serum Pi (mg·dL−1)	7.71 ± 0.16	8.09 ± 0.43	7.72 ± 0.12	8.03 ± 0.31	7.40 ± 0.15	8.01 ± 0.23	8.34 ± 0.20	8.48 ± 0.25

Rats were treated as in Figure 5. Data presented are means ± SEM (n = 8–11 per group).

One-way anova Dunnett's test with 95% confidence intervals of difference was performed for statistical comparisons:

^***P < 0.001 versus Sham Day 0.