Figure 8.
Inhibition of the production of proinflammatory cytokines in joint tissues and sera from mice with CIA and pretreated with SPA0355. Mice were injected with vehicle or SPA0355 (10 mg·kg−1) on day 20. Hind paws and sera were collected on day 45 from mice with CIA as well as from normal mice. Cytokines in joint homogenates (A) and sera (B) were measured by specific elisa. Values are the mean ± SEM of three independent experiments (n = 8–9 mice per group). *P < 0.05, **P < 0.01 significantly different from untreated CIA.