Figure 1.

Paclitaxel-induced hyperalgesia in kinin receptor-deficient mice. Mechanical (A) and thermal (B) withdrawal threshold of vehicle-treated wild-type (WT vehicle) mice, paclitaxel-treated WT (WT PTX) mice, paclitaxel-treated B₁R^−/−, (B₁R^−/− PTX) B₂R^−/− (B₂R^−/− PTX) and B₁B₂R^−/− (B₁B₂R^−/− PTX) mice were evaluated at different time intervals after the first paclitaxel treatment. (C, D) Inhibition of the AUC 0–6 h (from day 0 to 21) of paclitaxel-induced mechanical (C) and thermal (D) hyperalgesia in kinin receptor-deficient mice. The inhibition is shown as the AUC of the test group (receptor knock-out PTX animals), as a percentage of the control AUC (WT PTX animals). Each group represents the mean of five to six animals, and the error bars indicate the SEM. *P < 0.05 significantly different from paclitaxel-treated WT mice (two-way anova followed by the Bonferroni post-test). BL, baseline withdrawal threshold. #P < 0.05, significantly different from B₁R^−/− or B₂R^−/− group (one-way anova followed by the Newman–Keuls post-test).