Figure 2.

Effect of treatment with selective kinin B₁ or B₂ receptor antagonists, DALBK (100 nmol·kg⁻¹, i.p.) and Hoe 140 (50 nmol·kg⁻¹, i.p.), respectively, on the genesis of paclitaxel-induced mechanical (A) and thermal (B) hyperalgesia in CD1 mice. The drugs were given twice a day (every 12 h) for 6 days, starting at the time of the first paclitaxel treatment. Each group represents the mean of five to six animals, and the error bars indicate the SEM. *P < 0.05, significantly different from paclitaxel-treated mice (two-way anova followed by the Bonferroni post-test). BL, baseline withdrawal threshold.