Figure 3.

Effect of treatment with selective kinin B₁R or B₂R antagonists, DALBK (100–300 nmol·kg⁻¹, i.p.) and Hoe 140 (30–100 nmol·kg⁻¹, i.p.), respectively, on established mechanical (A, B, C) and thermal (D, E) hyperalgesia induced by paclitaxel in CD1 mice. A single injection of the drugs was given 7 (A, B, D) and 14 (C, E) days after the first paclitaxel (PTX) injection. (F) Effect of the repeated treatment with DALBK (100 nmol·kg⁻¹, i.p.) or Hoe 140 (50 nmol·kg⁻¹, i.p.), every 12 h for 2 days, on the sustained mechanical hyperalgesia in CD1 mice. Each group represents the mean of five to six animals, and the error bars indicate the SEM. *P < 0.05, significantly different from paclitaxel-treated mice (two-way anova followed by the Bonferroni post-test). BL, baseline withdrawal threshold.