Figure 5.

Effect of i.t. (A, B) or i.c.v. (C, D) treatment with selective kinin B₁ or B₂ receptor antagonists, DALBK (10 pmol) and Hoe 140 (100 pmol), respectively, on paclitaxel-induced mechanical hyperalgesia in CD1 mice. A single injection of the drugs was given 7 (A, C) and 14 (B, D) days after the first paclitaxel (PTX) injection. Each group represents the mean of five to six animals, and the error bars indicate the SEM. *P < 0.05, significantly different from paclitaxel-treated mice (two-way anova followed by Bonferroni post-test). BL, baseline withdrawal threshold.