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. 2011 Jul 19;105(5):628–639. doi: 10.1038/bjc.2011.240

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Copyright © 2011 Cancer Research UK

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An example of a study involving continuous reassessment methodology. Patients receive standard radical RT (e.g., 70 Gy in 35 fractions) and receive the IMP according to predefined dose streams and within dose bands. This design allows for simultaneous evaluation of different doses and durations of exposure to the IMP.