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. 2011 Aug 9;105(5):687–693. doi: 10.1038/bjc.2011.306

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Copyright © 2011 Cancer Research UK

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Effect of JNK inhibition on HLA1 expression. HCT116 and MCF7 cells were treated with BCG supernatant +/− the JNK inhibitor SP600125, and the effect of reduced JNK action on HLA1 expression assessed. The increase in phosphorylated JNK induced by BCG supernatant was negated by SP600125 (A), and the ability of BCG supernatant to enhance HLA1 expression compromised by JNK inhibition (B and C). Representative histograms from MCF7 experiments are shown (B), and each data column shows means and s.d.'s of a minimum of four separate experiments.