Table 1.
Haplotypes in CLOCK gene and breast cancer risk
| ER/PR + | ER/PR − | |||||||
|---|---|---|---|---|---|---|---|---|
| Common or Variant Allele* |
Frequency % |
Controls N |
Cases N |
OR† (95% CI) |
Cases N |
OR† (95% CI) |
Cases N |
OR†(95% CI) |
| CVCCVCCCC | 33.48% | 321 | 286 | 0.95 (0.78-1.16) | 54 | 0.94 (0.66-1.36) | 44 | 0.68 (0.46-0.99) |
| VCCCCVVCV | 23.65% | 216 | 215 | 1.18 (0.95-1.48) | 38 | 1.13 (0.75-1.70) | 48 | 1.54 (1.04-2.27) |
| CCVVCCCVC | 18.47% | 191 | 143 | 0.78 (061-1.00) | 29 | 0.79 (0.51-1.24) | 31 | 0.88 (0.57-1.36) |
| CCVVCVCVC | 12.74% | 120 | 110 | 0.97 (0.73-1.28) | 22 | 1.02 (0.62-1.70) | 25 | 1.17 (0.72-1.91) |
| CCVCCCCVC | 4.27% | 40 | 35 | 0.98 (0.61-1.57) | 5 | 0.78 (0.29-2.07) | 5 | 0.87 (0.32-2.32) |
| VVCCCVVCV | 3.56% | 24 | 38 | 1.87 (1.10-3.18) | 11 | 2.25 (1.04-4.87) | 6 | 1.33 (0.52-3.43) |
|
Protective
Allele |
36.49% | 363 | 293 | 0.81 (0.66-0.98) | 58 | 0.82 (0.57-1.17) | 61 | 0.91 (0.63-1.29) |
| 1+ Risk Alleles | 42.81% | 386 | 389 | 1.23 (1.01-1.48) | 76 | 1.27 (0.90-1.79) | 85 | 1.51 (1.07-2.14) |
| 2+ Risk Alleles | 28.43% | 265 | 250 | 1.31 (1.06-1.61) | 51 | 1.32 (0.90-1.92) | 57 | 1.59 (1.10-2.30) |
| 3 Risk Alleles | 28.11% | 249 | 260 | 1.28 (1.04-1.58) | 49 | 1.26 (0.86-1.84) | 57 | 1.60 (1.11-2.32) |
*
SNP order: rs7698022, rs6850524, rs11133391, rs11133389, rs13102385, rs11932595, rs1801260, rs3749474, rs1048004
†
Adjusted for age, race, family history of breast cancer, study site, menopausal status, age at menarche, and parity.