Table 2.
Molecules in the highest confidence (P=1.0E−41) network of genes differentially expressed following CLOCK knockdown.
| Symbol | Accession | Relevant Functions | Fold change |
Q-Value |
|---|---|---|---|---|
| ANTXR1 | NM_032208 | Angiogenesis, Cell Migration - Elevated in Tumors | 2.39 | 4.97E-05 |
| ANXA1 | NM_000700 | Malignant Transformation - Lost in Most Breast Carcionomas | 5.62 | 1.67E-11 |
| Ap1 | NM_002228 | Transcription Factor, Tumor Promotion | 1.30 | 3.18E-01 |
| AVP | NM_000490 | Growth Factor, Cell Cycle Progression | −2.00 | 1.18E-03 |
| BDKRB2 | NM_000623 | Breast Cell Proliferation | −2.06 | 1.63E-03 |
| CAPN8 | XM_938885 | Membrane Trafficking, Estrogen Responsive | 2.36 | 8.29E-04 |
| CCL5 | NM_002985 | Cell Cycle Progression, Elevated in Breast Carcinomas | −2.94 | 3.17E-06 |
| CD36 | NM_001001547 | Inhibitor of Angiogenesis, Down-Regulated by Estradiol | 2.94 | 1.25E-05 |
| CHGA | NM_001275 | Estrogen Receptor Responsive, Associated with ERa positivity | −2.27 | 8.12E-04 |
| GAB2 | NM_012296 | Cell Proliferation and Breast Carcinogenesis | −2.02 | 1.76E-03 |
| HOXA7 | NM_006896 | Transcription Factor, Inhibits Differentiation | 2.54 | 1.21E-03 |
| IL29 | NM_172140 | Cytokine with Antiviral and Antiproliferative Activity | −2.20 | 3.99E-03 |
| MGAT3 | AK125361 | Glycosyltransferase, Inhibits Tumor Metastisis | −2.91 | 1.02E-03 |
| MIF | NM_002415 | Cytokine, Enhances Tumor Growth and Angiogenesis | 2.04 | 7.63E-05 |
| S100P | NM_005980 | Induction of Metastisis and Breast Tumor Progression | −2.29 | 5.99E-05 |
| TNFRSF11B | NM_002546 | Cancer Cell Migration and Differentiation | 2.18 | 1.65E-08 |
| TNFRSF4 | NM_003327 | Member of the TNFR Superfamily, Facilitates Tumor Rejection | −2.32 | 1.57E-02 |
| UGT2B10 | NM_001075 | Phase II Metabolic Enzyme | 2.20 | 2.78E-04 |
| UGT2B15 | NM_001076 | Phase II Metabolic Enzyme, Regulated by Androgen and Estrogen | 2.74 | 2.44E-06 |
| UGT2B17 | NM_001077 | Phase II Metabolic Enzyme, Regulated by Androgen | 3.36 | 6.37E-05 |
| VTN | NM_000638 | Cellular Adhesion and Migration | −2.69 | 3.78E-04 |
Note: The following transcripts were included in the network, but refer to a gene family or other molecule with no unique mRNA transcript for assignment of fold change or P-value, and were thus excluded from the table: Glucuronosyltransferase, Calpain, Creb, ERK, MAPK, IL1, LDL, PI3K Pkc(s), PLC, PLD, STAT, Tgf beta, and UGT.