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The effect of S3I-201 in a neonatal PKD model
| Number of animals | Body weight (g) | Kidney weight (mg) | K/BW ratio (mg/g) | Cyst volume (%) | Cyst number | Serum creatinine (mg/dl) | |
|---|---|---|---|---|---|---|---|
| Vehicle | 4 (3 m, 1 f) | 21.6± 4.5 | 348.2± 23.7 | 16.5± 2.9 | 42± 8 | 146± 59 | 0.27± 0.06 |
| S3I-201 | 5 (2 m, 3 f) | 21.3± 3.1 | 232.5± 64.7 | 10.9± 2.9 | 18± 11 | 34± 23 | 0.13± 0.10 |
| P-value | NS | P< 0.006 | P< 0.01 | P< 0.004 | P< 0.003 | P< 0.04 |
m, male; f, female.
