FIG. 3.

The scanned H&E-stained tumor sections from control rats and rats treated with intravenously injected Doxil or ¹⁸⁶Re-Doxil show the presence of viable tumor cells stained with hematoxylin (A). Control tumor was collected on day 20 post–therapy, whereas tumors from the intravenous Doxil- or ¹⁸⁶Re-Doxil-treated groups were collected on day 28 post-therapy. Viable tumor cells with regions of necrosis are present in the tumors of control and treated rats. H&E-stained tumor sections and corresponding Ki67-stained tumor sections were compared to correlate localization of staining (B) and area measurement (C). H&E, hematoxylin and eosin. Color images available online at www.liebertonline.com/cbr