FIG. 4.

The area of tumor microscopic section that was stained with hematoxylin, representing viable tumor cells as a function of the entire tumor microscopic specimen area (microscopic viability factor), was determined for treated groups and control (A) (*p<0.05, control vs. 740 MBq/kg of ¹⁸⁶Re-Doxil) and applied to the tumor volume on the day of necropsy to calculate viable tumor volume (B). Animals treated with ¹⁸⁶Re-Doxil and Doxil had a smaller viable tumor volume than rats treated with ¹⁸⁶Re-PEG-liposomes and control rats. *p<0.05, Doxil vs. 740 MBq/kg of ¹⁸⁶Re-Doxil; ***p<0.001, control vs. 740 MBq/kg of ¹⁸⁶Re-Doxil and control vs. 555 MBq/kg of ¹⁸⁶Re-Doxil.