Table 1.
Experimental Groups Intravenously Injected with Escalating Radioactivities in MBq/kg of 186Re-Doxil and 186Re-Polyethylene Glycol-Liposomes and the Control Groups
| Therapeutic agent | Number of rats | Injected radioactivity MBq/kg | Injected lipid dose mg/kg | Injected doxorubicin dose mg/kg | Mean±SD of body weight loss (% of body weight compared with day 0) |
|---|---|---|---|---|---|
| Control | 6 | 0 | 0 | 0 | |
| Doxil | 4 | 0 | 52 | 6.5 | 7.6±1.9 |
| 186Re-Doxil | 2 | 925 | 52 | 6.5 | 19. 9±6.6 |
| 186Re-Doxil | 4 | 740 | 52 | 6.5 | 13.8±5.2 |
| 186Re-Doxil | 4 | 555 | 52 | 6.5 | 11.8±4.7 |
| 186Re-Doxil | 4 | 370 | 52 | 6.5 | 11.1±4.3 |
| 186Re-Doxil | 2 | 185 | 52 | 6.5 | 10.9±0.8 |
| 186Re-PEG-liposomes | 4 | 1665 | 52 | 0 | 19.8±4.9 |
| 186Re-PEG-liposomes | 4 | 1480 | 52 | 0 | 13.8±7.0 |
| 186Re-PEG-liposomes | 4 | 1295 | 52 | 0 | 11.3±8.8 |
| 186Re-PEG-liposomes | 4 | 1110 | 52 | 0 | 9.5±4.9 |
| 186Re-PEG-liposomes | 4 | 925 | 52 | 0 | 9.4±6.1 |
| 186Re-PEG-liposomes | 4 | 740 | 52 | 0 | 6.9±2.7 |
The decrease in body weight on day 5 postinjection of the different treated groups compared with their body weight on day 0. Mean±SD are shown.
PEG, polyethylene glycol.