. 2011 Oct;26(5):603–614. doi: 10.1089/cbr.2010.0948

Table 2.

Radiation Absorbed Dose (in Gy and Gy/MBq) by Tumor and Normal Organs for the Different Injected Doses of ¹⁸⁶Re-Doxil and ¹⁸⁶Re-Polyethylene Glycol-Liposomes

		Total radiation absorbed dose (Gy)							Normalized radiation absorbed dose (Gy/MBq)
Therapy	Injected activity (MBq/kg)	Tumor	Liver	Spleen	Left Kidney	Right Kidney	Heart	Lungs	Tumor	Liver	Spleen	Left kidney	Right kidney	Heart	Lungs
¹⁸⁶Re-Doxil	925	54.4±2.7	48.4±21.3	163.3±11.6	198.1±3.3	168. 5±1.5	32.9±5.3	84.9±14.7	0.265±0.029	0.235±0.001	0.792±0.01	0.962±0.04	0.819±0.04	0.159±0.016	0.411±0.048
¹⁸⁶Re-Doxil	740	46.8±21.3	37.7±4.3^**	136.1±21.9	150.8±12.3^*	137.2±5.5^*	26.3±3.0	68.0±5.7^*	0.299±0.109^*	0.250±0.046	0.895±0.146^**	0.994±0.115^*	0.905±0.094^*	0.170±0.019^**	0.44±0.037^**
¹⁸⁶Re-Doxil	555	32.2±8.7	30.3±5.1	122.3±26.7	128.6±27.2	116.9±23.0	20.2±3.4	52.6±11.5	0.273±0.099	0.248±0.033	0.991±0.052	1.045±0.077	0.952±0.063	0.130±0.022	0.340±0.074
¹⁸⁶Re-Doxil	370	30.4±5.1	22.2±3.8	84.0±16.0	97.1±0.5	90.9±0.3	15.9±1.9	43.4±0.2	0.377±0.071	0.273±0.022	1.032±0.122	1.201±0.063	1.124±0.096	0.103±0.012	0.281±0.04
¹⁸⁶Re-Doxil	185	14.5±1.0	11.9±1.7	56.3±0.8	44.7±0.3	40.7±0.4	8.0±0	22.7±0.9	0.334±0.062	0.270±0.006	1.280±0.019	1.013±0.022	0.925±0.032	0.118±0.022	0.277±0.081
¹⁸⁶Re-PEG-liposomes	1665	38.5±5.9	86.2±20.7	203.0±94.4	239.6±40.4	241.1±38.4	29.2±6.4	75.8±2.5	0.120±0.008	0.266±0.037	0.617±0.225	0.744±0.054	0.754±0.118	0.098±0.022	0.255±0.042
¹⁸⁶Re-PEG-liposomes	1480	31.6±7.0	71.3±14.5	139.2±33.9	214.4±41.4	210.9±31.5	22.5±3.3	57.1±0.3	0.120±0.038	0.262±0.021	0.510±0.066	0.790±0.076	0.781±0.072	0.076±0.011	0.192±0.018
¹⁸⁶Re-PEG-liposomes	1295	28.5±3.7	68.9±18.8	119.9±8.5	188.4±13.4	185.1±17.4	20.0±3.8	49.2±0.3	0.110±0.0003	0.264±0.044	0.467±0.056	0.731±0.048	0.716±0.039	0.067±0.013	0.166±0.035
¹⁸⁶Re-PEG-liposomes	1110	23.0±2.4	52.0±3.4	106.8±11.1	146.8±8.5	144.7±4.0	17.6±0.9	45.0±0.8	0.119±0.010	0.270±0.025	0.552±0.056	0.760±0.052	0.749±0.032	0.059±0.003	0.152±0.016

Values are presented as mean±SD. ^*p<0.05, ^**p<0.01: 740 MBq/kg of ¹⁸⁶Re-Doxil compared with 1480 MBq/kg of ¹⁸⁶Re-PEG-liposomes.