Table 3.

Log-Rank Test on OS for Combination of VEGF and IGF-1 Levels

Combination	Patients (No.)	Deaths (No.)	Median OS (months)	95% CI	P
Low/high (VEGF ≤ 450 pg/mL; IGF-1 > 26 ng/mL)	191	135	19.00	13.64 to 23.90	< .001
High/high (VEGF > 450 pg/mL; IGF-1 > 26 ng/mL)	37	29	13.22	9.60 to 26.79	< .001
Low/low (VEGF ≤ 450 pg/mL; IGF-1 ≤ 26 ng/mL)	41	36	9.83	5.85 to 16.47	< .001
High/low (VEGF > 450 pg/mL; IGF-1 ≤ 26 ng/mL)	19	17	2.70	2.27 to 4.04	< .001

Abbreviations: IGF-1, insulin-like growth factor-1; OS, overall survival; VEGF, vascular endothelial growth factor.