Table A3.
Log-Rank Test on OS for BCLC Stages Split by IGF-1 Level*
| BCLC Stage | Patients (No.) | Events (No.) | Median OS (months) | 95% CI | P |
|---|---|---|---|---|---|
| 0 | .8015 | ||||
| All patients | 21 | 7 | 49.08 | 33.99 to NA | |
| IGF-1 level | |||||
| 0 | 17 | 6 | 49.08 | 33.99 to NA | |
| 1 | 4 | 1 | NA | 6.84 to NA | |
| A | .52 | ||||
| All patients | 28 | 12 | 40.67 | 27.09 to NA | |
| IGF-1 level | |||||
| 0 | 24 | 10 | 40.67 | 33.7 to NA | |
| 1 | 4 | 2 | 18.51 | 12.95 to NA | |
| B | .125 | ||||
| All patients | 29 | 23 | 22.68 | 16.14 to 28.64 | |
| IGF-1 level | |||||
| 0 | 23 | 17 | 23.57 | 16.14 to 29.88 | |
| 1 | 6 | 6 | 16.88 | 14.89 to NA | |
| C | < .001 | ||||
| All patients | 189 | 156 | 11.15 | 8.58 to 13.61 | |
| IGF-1 level | |||||
| 0 | 152 | 121 | 12.43 | 10.13 to 17.75 | |
| 1 | 37 | 35 | 5.06 | 4.01 to 11.9 | |
| D | .0136 | ||||
| All patients | 21 | 19 | 2.93 | 2.14 to 9.14 | |
| IGF-1 level | |||||
| 0 | 12 | 10 | 6.44 | 2.40 to NA | |
| 1 | 9 | 9 | 2.2 | 0.62 to NA |
Abbreviations: BCLC, Barcelona Clinic Liver Cancer; IGF-1, insulin-like growth factor-1; NA, not applicable; OS, overall survival.
*
IGF-1 level: 0 if IGF-1 > 26 ng/mL; 1 if IGF-1 ≤ 26 ng/mL.