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. 2011 Aug 11;3:19. doi: 10.1186/2045-824X-3-19

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Copyright ©2011 Adepoju et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Quantitative PCR results of HES/HEY genes after treatment with gamma secretase inhibitor. Transcript levels of HES/HEY genes in HemSCs are changed with administration of a gamma secretase inhibitor (GSI), Compound E. HEY1 (left) transcripts were universally decreased after GSI treatment, although only statistically significant for H37 (p = 0.01). HEYL (middle) transcripts were decreased in H37, (p = 0.02), but baseline transcript levels were too low for the other 2 cell lines for meaningful comparison. HES1 (right) transcripts were universally decreased and were statistically significant for H37 (p = 0.02) and H41 (p = 0.03). It was not significant for H40 (p = 0.1).