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. 1984 Jul 11;12(13):5265–5275. doi: 10.1093/nar/12.13.5265

Molecular footprints of human immunoglobulin gene evolution: a new sequence family.

B Straubinger, M Pech, K Mühlebach, H R Jaenichen, H G Bauer, H G Zachau
PMCID: PMC318918  PMID: 6087280

Abstract

Analysis of the human VK (ref. 2) gene locus led to the detection of a new sequence family (L sequences). Its copy number is in the range of 10(2). The L sequences, which are about 500 bp long, are found as part of the 3' flanking regions of a clustered set of human VKI genes but they occur also separate from the genes. Models are discussed in which L sequences are viewed as molecular footprints of amplification and transposition processes of VK genes.

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Selected References

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