Table 6. Immunodominant CSP and AMA1 peptide pools by ELISpot assay.
Group 1 | Group 2 | |||||||||||
Cp | 10 d | 28 d | 4 m | 7 m | 10 m | 12 m | 10 d | 28 d | 4 m | 7 m | 10 m | 12 m |
1 | 1 | 3 | 3 | 1 | 2 | 2 | 1 | |||||
2 | 6 | 5 | 3 | 2 | 2 | 2 | 1 | |||||
3 | ||||||||||||
4 | ||||||||||||
5 | ||||||||||||
6 | 2 | 1 | 1 | 1 | 1 | 1 | ||||||
7 | ||||||||||||
8 | ||||||||||||
9 | 3 | 3 | 1 | 4 | 1 | 1 |
The peptide pools that were most strongly recognized at each time point by a volunteer demonstrating an overall positive response were arbitrarily identified as immunodominant if the response to that pool exceeded one-third the value of the responses to the pool with the peak response in that volunteer. The number of volunteers who met criteria for immunodominance for a given peptide pool is shown in each box. Responses to CSP pools were consistent in both Groups but more variable to AMA1 in Group 1 and Group 2.