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. Author manuscript; available in PMC: 2011 Oct 7.
Published in final edited form as: Neuron. 2010 Nov 18;68(4):763–775. doi: 10.1016/j.neuron.2010.09.025

Figure 3.

Figure 3

Synaptic plasticity uniformly scales synaptic currents evoked by stimulus trains. (A) EPSCs measured during vestibular nerve stimulation at 10 Hz rapidly reach a steady-state plateau of 49 ± 4% (EPSC11–20) of the EPSC amplitude response to a single stimulus (EPSC1) before LTD induction and 50 ± 4% after. (B) Short-term synaptic dynamics also did not change following LTP, in which the steady-state plateau was 59 ± 4% before and 55 ± 3% after induction. (C) Steady-state EPSCs evoked during stimulus trains (5–100 Hz) were measured following LTD and LTP induction to assess short-term dynamics over the physiological range of the synapse. The total synaptic charge transfer per unit time increased linearly with vestibular nerve stimulation rate. Steady-state charge transfer was calculated as the integrated area under the average steady-state EPSC, normalized to the charge transfer of the first EPSC in the train.