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Plasticity in interneurons is dominated by NMDA-R-mediated LTD. (A) Inclusion of 5 mM BAPTA in the recording pipette abolished LTD induced by the 100 Hz stim protocol, as did (B) bath application of 100 μM D-APV. (C) Bath application of 100 μM D-APV during the 100 Hz stim plus hyperpolarization protocol unmasked an underlying LTP. (D) 10 μM Philanthotoxin-433 blocked the unmasked LTP.
