Figure 6. A CML-like disease in mice deficient for Irf8 and Irf4.

(A) Spleens (left panel) and spleen weight of WT, Irf8 ^-/-, Irf4 ^-/-, and DKO mice. Values are mean ± standard deviation from measurements of 5 to 6 spleens of each genotype. *P<0.01 (Student's t-test). (B) Flow cytometric analysis of granulocytes (CD11b⁺ Gr1⁺) and macrophages (F4/80⁺) in bone marrow cells (upper panels) and splenocytes (lower panels). Numbers indicate the percentages of granulocytes and macrophages. Data are representative of three independent experiments with similar results. (C) The absolute numbers of granulocytes and macrophages per femur (upper part) or spleen (lower part). The ratios of granulocytes to macrophages are shown in the right panels. Values are mean ± standard deviation from 3 to 5 mice of each genotype. *P<0.01 and **P<0.05 (Student's t-test).