Table 1. Effects of 0.5 mg/kg amphetamine (AMPH), the CB1 receptor antagonist/inverse agonist SR141716A (SR) and their combination on measures of attentional function, compulsivity, and motivation in the 5-CSRTT.
Treatment (mg/kg) | Accuracy (%) | Perseverative responses | Correct response latency (ms) | Omissions | Feeder latency (ms) |
Vehicle–Vehicle<\emph> | 94.6±0.9 | 6.8±1.6 | 598±22 | 10.5±3.1 | 1632±106 |
Vehicle–SR 1<\emph> | 94.8±0.8 | 7.0±1.0 | 627±34 | 12.8±4.0 | 1727±137 |
Vehicle–SR 3<\emph> | 93.0±1.5 | 6.4±1.1 | 620±31 | 13.2±3.6 | 2038±365 |
AMPH–Vehicle<\emph> | 86.2±1.4** | 6.4±1.4 | 534±21* | 8.5±2.5 | 1441±101 |
AMPH–SR 1<\emph> | 88.7±1.0** | 15.6±5.4 | 564±25 | 7.6±1.6 | 2139±342 |
AMPH–SR 3<\emph> | 89.8±1.3** # | 12.2±2.4 | 577±20 | 9.1±1.4 | 2168±359 |
In total n = 13 animals were included in the analyses and data depict mean±SEM.
*p<0.05.
**p<0.005 versus Vehicle-Vehicle.
p<0.05 compared to AMPH-Vehicle.