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. 2011 Oct 7;6(10):e25856. doi: 10.1371/journal.pone.0025856

Table 1. Effects of 0.5 mg/kg amphetamine (AMPH), the CB1 receptor antagonist/inverse agonist SR141716A (SR) and their combination on measures of attentional function, compulsivity, and motivation in the 5-CSRTT.

Treatment (mg/kg) Accuracy (%) Perseverative responses Correct response latency (ms) Omissions Feeder latency (ms)
Vehicle–Vehicle<\emph> 94.6±0.9 6.8±1.6 598±22 10.5±3.1 1632±106
Vehicle–SR 1<\emph> 94.8±0.8 7.0±1.0 627±34 12.8±4.0 1727±137
Vehicle–SR 3<\emph> 93.0±1.5 6.4±1.1 620±31 13.2±3.6 2038±365
AMPH–Vehicle<\emph> 86.2±1.4** 6.4±1.4 534±21* 8.5±2.5 1441±101
AMPH–SR 1<\emph> 88.7±1.0** 15.6±5.4 564±25 7.6±1.6 2139±342
AMPH–SR 3<\emph> 89.8±1.3** # 12.2±2.4 577±20 9.1±1.4 2168±359

In total n = 13 animals were included in the analyses and data depict mean±SEM.

*p<0.05.

**p<0.005 versus Vehicle-Vehicle.

#

p<0.05 compared to AMPH-Vehicle.