Table 2. Results of 10 mg/kg PTZ screen.
Mean (±SEM) | p-Value | N | ||
Wildtype | Pum2XE772 | |||
10 mg/kg | ||||
Event count after 1st injection | 0.5±0.38 | 21.5±9.07 | 0.0052 ** | 8; 8 |
Event count after 2nd injection | 9.63±3.25 | 46.25±10.97 | 0.0054 ** | 8; 8 |
45 mg/kg | ||||
Time until 1st event (s) | 159.9±42.67 | 70.00±13.88 | 0.0403 * | 8; 8 |
Time until seizure (s) | 558.6±124.4 | 265.5±82.73 | 0.065 | 8; 8 |
Time: 1st spike – seizure (s) | 398.8±92.16 | 195.5±71.68 | 0.03 * | 8; 8 |
Duration of seizure (behavioral events, s) | 18.72±1.91 | 45.12±4.8 | 0.0079 ** | 5; 5 |
Event count after seizure (3 h) | 57.00±23.48 | 147.9±36.74 | 0.0289 * | 8; 7 |
*p<0.05;
**p<0.01.