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Sirtuin-3-mediated cyclophilin D deacetylation triggers hexokinase II detachment. Transfer to galactose-based medium causes an increase in the expression and activity of sirtuin-3. In turn, sirtuin-3 (Sirt-3) promotes deacetylation of cyclophilin D (Cyp-D), causing it to dissociate from ANT1, which then promotes the detachment of hexokinase II (HXK II) from the mitochondria. VDAC, voltage-dependent anion channel.
