Table 2.
Associations between baseline characteristics and risk of hematologic malignancies
| Characteristic | Cases (n=588) n (%) |
Noncases (n=65,639) n (%) |
Age- and sex-adjusted HR (95% CI) |
|---|---|---|---|
| Demographic Factors | |||
| Age at baseline, n (%) | N/A | ||
| <55 years | 47 (8.0) | 16,459 (25.1) | |
| 55 to <60 years | 111 (18.9) | 15,531 (23.7) | |
| 60 to <65 years | 97 (16.5) | 11,945 (18.2) | |
| 65 to <70 years | 123 (20.9) | 10,339 (15.8) | |
| ≥70 years | 210 (35.7) | 11,365 (17.3) | |
| Gender, n (%) | |||
| Female | 232 (39.5) | 33,408 (50.9) | 1.00 (Reference) |
| Male | 356 (60.5) | 32,231 (49.1) | 1.67 (1.42–1.98) |
| Race/Ethnicity, n (%) | |||
| White | 544 (94.0) | 60,047 (93.0) | 1.00 (Reference) |
| Hispanic | 8 (1.4) | 577 (0.9) | 1.81 (0.90–3.65) |
| Other | 27 (4.7) | 3,916 (6.1) | 0.80 (0.54–1.18) |
| Education, n (%) | |||
| High School Graduate or Less | 127 (21.9) | 12,532 (19.4) | 1.00 (Reference) |
| Some College | 200 (34.5) | 24,711 (38.3) | 0.96 (0.77–1.20) |
| College or Advanced Degree | 252 (43.5) | 27,316 (42.3) | 1.08 (0.86–1.34) |
| Lifestyle | |||
| Smoking Status | |||
| Never Smoker, n (%) | 259 (44.1) | 31,381 (47.8) | |
| Pack-years, mean (SD)* | 28.1 (24.0) | 25.6 (23.2) | 1.00 (0.99–1.00) |
| Medical History | |||
| Self-reported Health, n (%) | |||
| Excellent | 66 (11.5) | 10,234 (15.8) | 1.00 (Reference) |
| Very Good | 218 (37.9) | 25,507 (39.5) | 1.24 (0.94–1.63) |
| Good | 209 (36.3) | 21,608 (33.4) | 1.34 (1.02–1.77) |
| Fair | 67 (11.7) | 6,254 (9.7) | 1.50 (1.07–2.10) |
| Poor | 15 (2.6) | 1,029 (1.6) | 2.34 (1.34–4.09) |
| History of Coronary Artery Disease, n (%) | |||
| No | 499 (84.9) | 59,913 (91.3) | 1.00 (Reference) |
| Yes | 89 (15.1) | 5,712 (8.7) | 1.25 (0.98–1.59) |
| History of Rheumatoid Arthritis, n (%) | |||
| No | 551 (93.7) | 63,200 (96.3) | 1.00 (Reference) |
| Yes | 37 (6.3) | 2,425 (3.7) | 1.60 (1.14–2.24) |
| History of Fatigue/Lack of Energy, n (%) | |||
| No | 480 (81.6) | 53,911 (82.2) | 1.00 (Reference) |
| Yes | 108 (18.4) | 11,714 (17.8) | 1.16 (0.94–1.43) |
| History of Anemia, n (%) | |||
| No | 565 (96.1) | 64,181 (97.8) | 1.00 (Reference) |
| Yes | 23 (3.9) | 1,444 (2.2) | 2.17 (1.42–3.30) |
| Family History of Leukemia/Lymphoma, n (%) | |||
| None | 533 (93.0) | 61,335 (94.6) | 1.00 (Reference) |
| 1 First-degree Relative | 34 (5.9) | 3,346 (5.2) | 1.15 (0.81–1.62) |
| ≥ 2 First-degree Relatives | 6 (1.0) | 147 (0.2) | 4.13 (1.84–9.25) |
*
Among smokers and former smokers.
Abbreviations: CI, confidence interval; HR, hazard ratio; SD standard deviation