Table 3.

Gene-vitamin D deficiency interactions on any food sensitization in 649 BMC subjects.

Interleukin-4 (IL4)
	rs2243250=TT			rs2243250=CC/CT

CBP 25(OH)D	Case/Control	OR (95%CI)	p-value	Case/Control	OR (95%CI)	p-value	p_interaction
>=11 ng/ml	63/69	Ref		61/168	ref
<11 ng/ml	39/61	0.60 (0.34 – 1.06)	0.08	77/107	1.79 (1.15 – 2.77)	0.01	0.003 ^*

membrane-spanning 4-domains, subfamily A, member 2 (MS4A2)
	rs512555=AA/AG			rs512555=GG

CBP 25(OH)D	Case/Control	OR (95%CI)	p-value	Case/Control	OR (95%CI)	p-value	p_interaction
>=11 ng/ml	30/29	Ref		94/210	ref
<11 ng/ml	18/32	0.40 (0.17 – 0.98)	0.04	98/138	1.43 (0.99 – 2.08)	0.06	0.009

IgE Fc receptor subunit gamma (FCER1G)
	rs2070901=GG			rs2070901=TT/TG

CBP 25(OH)D	Case/Control	OR (95%CI)	p-value	Case/Control	OR (95%CI)	p-value	p_interaction
>=11 ng/ml	49/84	Ref		75/154	ref
<11 ng/ml	38/68	0.69 (0.38 – 1.25)	0.23	78/102	1.52 (1.00 – 2.33)	0.05	0.04

cytochrome P450, family 24, subfamily A, polypeptide 1
	rs2762934=GG			rs2762934=AA/AG

CBP 25(OH)D	Case/Control	OR (95%CI)	p-value	Case/Control	OR (95%CI)	p-value	p_interaction
>=11 ng/ml	86/157	Ref		38/82	ref
<11 ng/ml	75/131	0.88 (0.58 – 1.32)	0.53	41/38	2.29 (1.22 – 4.32)	0.01	0.02

FDR-corrected p=0.10. All the OR estimates were adjusted for age, sex, maternal smoking after birth, breast feeding, and ancestry proportion.