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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Nat Nanotechnol. 2011 Sep 11;6(10):658–667. doi: 10.1038/nnano.2011.105

Figure 1. Sequence and secondary structure of phi29 DNA-packaging RNA (pRNA).

Figure 1

a, Illustration of the phi29 packaging motor geared by six pRNAs (orange, pink, light blue, green, dark blue and yellow structures). b, Schematic showing a pRNA hexamer assembled through hand-in-hand interactions of six pRNA monomers. c, Sequence of pRNA monomer Ab′. Green box: central 3WJ domain. Uppercase and lowercase letters in Ab′ represent right- and left-hand loops, respectively. d, The 3WJ domain composed of three RNA oligomers in black, blue and red. Helical segments are represented as H1, H2, H3. e, A trivalent RNA nanoparticle consisting of three pRNA molecules bound at the 3WJ-pRNA core sequence (red, black and blue) and its accompanying AFM images (f). Ab′ indicates non-complementary loops35.