Table 2. E16.5 murine brain CrkL-SH3 binding proteins within PANTHER gene ontology categories Cell Adhesion and Cell Communication.
PANTHER gene ontology classification was performed as described in the text and proteins in each category are listed. Additionally, each protein was searched for a possible Src substrate motif as described in the text. Identified Src substrate motifs were predicted by Scansite and their stringency is indicated (high, medium or low). None denotes no Src substrate motif was identified.
| Protein Description | Scansite | |
|---|---|---|
| Protein | Cell Adhesion (PANTHER Category) | Src target |
| Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | medium |
| Ctnnd1 | Catenin delta-1 | medium |
| Ddef2 (Asap2) | Development and differentiation-enhancing factor 2 | medium |
| Abl1 | Proto-oncogene tyrosine-protein kinase ABL1 | low |
| Abl2 | Tyrosine-protein kinase ABL2 | low |
| ARAP1 | Arf-GAP, Rho-GAP domain, ANK repeat and PH domain-containing protein 1 | low |
| Sema6d | Semaphorin-6D | none |
| Cell Communication (PANTHER Category) | ||
| Dock4 | Dedicator of cytokinesis protein 4 | high |
| Pik3cb | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform | high |
| Pik3r2 | Phosphatidylinositol 3-kinase regulatory subunit beta | high |
| Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | medium |
| Ctnnd1 | Catenin delta-1 | medium |
| Cyfip2 | Cytoplasmic FMR1-interacting protein 2 | medium |
| Ddef2 (Asap2) | Development and differentiation-enhancing factor 2 | medium |
| Dock3 | Dedicator of cytokinesis protein 3 | medium |
| Dock5 | Dedicator of cytokinesis protein 5 | medium |
| Snx26 (Arhgap33) | TC10/CDC42 GTPase-activating protein | medium |
| Sos1 | Son of sevenless homolog 1 | medium |
| Abl1 | Proto-oncogene tyrosine-protein kinase ABL1 | low |
| Abl2 | Tyrosine-protein kinase ABL2 | low |
| ARAP1 | Arf-GAP, Rho-GAP domain, ANK repeat and PH domain-containing protein 1 | low |
| Caskin1 | Caskin-1 | low |
| Cbl | E3 ubiquitin-protein ligase CBL | low |
| Cblb | E3 ubiquitin-protein ligase CBL-B | low |
| Dock1 | Dedicator of cytokinesis protein 1 | low |
| Eps15 | Epidermal growth factor receptor substrate 15 | low |
| Eps15l1 | Epidermal growth factor receptor substrate 15-like 1 | low |
| Inppl1 | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 | low |
| Itsn1 | Intersectin-1 | low |
| Phldb1 | Pleckstrin homology-like domain family B member 1 | low |
| RAPGEF1 (C3G) | Rap guanine nucleotide exchange factor 1 | low |
| Rics (Arhgap32) | Rho/Cdc42/Rac GTPase-activating protein RICS | low |
| Sec23a | Protein transport protein Sec23A | low |
| Sh3bp1 | SH3 domain-binding protein 1 | low |
| Sh3pxd2b | SH3 and PX domain-containing protein 2B | low |
| Sos2 | Son of sevenless homolog 2 | low |
| Trim67 | Tripartite motif-containing protein 67 | low |
| Brsk2 | BR serine/threonine-protein kinase 2 | none |
| EEF1A1 | Elongation factor 1-alpha 1 | none |
| Lats1 | Serine/threonine-protein kinase LATS1 | none |
| Lpp | Lipoma-preferred partner homolog | none |
| RAPH1 | Ras-associated and pleckstrin homology domains-containing protein 1 | none |
| Sema6d | Semaphorin-6D | none |
| Sh3d19 | SH3 domain-containing protein 19 | none |
| Synj1 | Synaptojanin-1 | none |