LV volumes and function measurements by 3DE : a intra-observer variability; b inter- observer variability. Legend: To study the reproducibility of LV volumes and EF measurements, we identified 16 studies including 407 patients in which reproducibility of these measurements by 3DE was assessed [4, 5, 13–17, 20, 22–25, 28, 30]. Studies are shown in chronological order, with the most recent publications to the right. Kühl et al. [4]: a TomTec CardioView RT semi-automated analysis, b TomTec CardioView RT manual analysis; Soliman et al. [22]: a TomTec 4D LV-Analysis ver. 2.0, b Philips QLAB V4.2; Hansegård et al. [30]: a TomTec 4D LV-Analysis ver. 2.2, b GE 4DLVQ software, EchoPAC ver. 108.1.0