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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Curr Opin Struct Biol. 2011 Aug 31;21(5):590–596. doi: 10.1016/j.sbi.2011.08.007

Figure 4. Post-translational processing of cell-surface O-glycosylated proteins.

Figure 4

Processing and nuclear entry of proteins are based on reports for MUC1 [54], Notch [55], dystroglycan (DG) [45,56], N-CAM [57], and CD43 [58]. Notch is processed by ADAM10 and ADAM17. Arrows refer to sites of cleavage: red, γsecretase (γ); green, SEA domain; yellow, ADAM; orange, furin (F); and purple, processing by other protease(s). For some proteins, the exact site of cleavage is not known. In parentheses is the predicted molecular weight of the proteins shown. Only O-glycan (not N-glycan) modifications are depicted.