Figure 6. Cl⁻ efflux following agents that increase intracellular Ca²⁺ concentrations.

A) Cl⁻ efflux in macrophages assessed in control solution following carbachol treatment (■) compared with Cl⁻ efflux under control conditions alone (□). (WT macrophages = 86 from 5 mice & CF macrophages = 203 from 5 ΔF508/ ΔF508 and 4 cftr^−/− mice).*p=0.019, **p<0.0001 B) Cl⁻ efflux in macrophages assessed in control solution following thapsigargin treatment () compared with Cl⁻ efflux under control conditions alone (□). (WT macrophages = 89 from 5 mice & CF macrophages = 77 from 4 ΔF508/ ΔF508 and 4 cftr^−/− mice) **p<0.0001. Only CF macrophages demonstrate increases in Cl⁻ efflux following treatment with either carbachol or thapsigargin.