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. Author manuscript; available in PMC: 2012 Nov 1.

Published in final edited form as: Pediatr Res. 2011 Nov;70(5):447–452. doi: 10.1203/PDR.0b013e31822f2448

A): Cl⁻ efflux in macrophages assessed in low Ca²⁺ solution following carbachol treatment (■) compared with Cl⁻ efflux under control conditions alone (□). (WT= 79 macrophages from 4 mice & CF = 138 macrophages from 4 ΔF508/ ΔF508 and 3 cftr^−/− mice). *p<0.0001 B): Cl⁻ efflux in macrophages assessed in low Ca²⁺ solution following thapsigargin treatment () compared with Cl⁻ efflux under control conditions alone (□). (WT = 27 macrophages from 3 mice & CF = 130 macrophages from 4 ΔF508/ ΔF508 and 4 cftr^−/− mice) *p <0.0001 Only CF macrophages demonstrate increases in Cl⁻ efflux following treatment with either carbachol or thapsigargin.

Inline graphic — A): Cl⁻ efflux in macrophages assessed in low Ca²⁺ solution following carbachol treatment (■) compared with Cl⁻ efflux under control conditions alone (□). (WT= 79 macrophages from 4 mice & CF = 138 macrophages from 4 ΔF508/ ΔF508 and 3 cftr^−/− mice). *p<0.0001 B): Cl⁻ efflux in macrophages assessed in low Ca²⁺ solution following thapsigargin treatment () compared with Cl⁻ efflux under control conditions alone (□). (WT = 27 macrophages from 3 mice & CF = 130 macrophages from 4 ΔF508/ ΔF508 and 4 cftr^−/− mice) *p <0.0001 Only CF macrophages demonstrate increases in Cl⁻ efflux following treatment with either carbachol or thapsigargin.