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. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: BJU Int. 2011 Jul 5;109(4):628–633. doi: 10.1111/j.1464-410X.2011.10400.x

TABLE 1.

Changes in cystometric parameters after intravenous (i.v.) BAM 8–22 administration in normal rats.

Variable	Vehicle	BAM 8–22, μg/kg
Variable	Vehicle	3	10	30	100
Number of rats	4	8	8	8	8
Mean ± SE
ICI, mins
before treatment	9.69 ± 2.26	9.96 ± 1.77	10.14 ± 1.36	9.99 ± 1.29	10.12 ± 1.44
after treatment	9.65 ± 2.11	9.99 ± 1.83	11.90 ± 1.04	14.16 ± 2.44^*^†	16.91 ± 3.08^*^†
BP, cmH₂O
before treatment	5.80 ± 0.77	5.44 ± 2.13	5.75 ± 1.68	5.40 ± 1.32	5.62 ± 1.51
after treatment	5.58 ± 1.06	5.50 ± 2.18	5.70 ± 1.59	5.42 ± 1.28	5.49 ± 1.40
PT, cmH₂O
before treatment	7.12 ± 0.45	7.99 ± 1.03	8.53 ± 1.64	8.12 ± 1.76	7.98 ± 1.75
after treatment	7.28 ± 0.52	8.04 ± 1.05	9.68 ± 1.55	12.44 ± 3.83^*^†	20.28 ± 4.26^*^†
MVP, cmH₂O
before treatment	27.5 ± 4.86	26.9 ± 3.65	26.1 ± 2.39	25.7 ± 2.08	26.1 ± 2.70
after treatment	27.7 ± 4.06	26.0 ± 3.22	26.1 ± 2.50	35.5 ± 1.62^*^†	40.4 ± 2.71^*^†
PVR, ml
before treatment	0.09 ± 0.03	0.09 ± 0.03	0.08 ± 0.02	0.09 ± 0.02	0.09 ± 0.02
after treatment	0.08 ± 0.04	0.08 ± 0.02	0.08 ± 0.02	0.09 ± 0.01	0.09 ± 0.03

^*

P <0.01 (paired t-test);

^†

P <0.01 vs vehicle injection (Dunnett’s multiple comparison test)