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. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: BJU Int. 2011 Jul 5;109(4):628–633. doi: 10.1111/j.1464-410X.2011.10400.x

TABLE 2.

Changes in cystometric parameters after intrathecal (i.t.) BAM 8–22 administration in normal rats.

Variable	Vehicle	BAM 8–22, μg
Variable	Vehicle	0.01	0.03	0.1	0.3
Number of rats	4	6	6	6	6
Mean ± SE
ICI, mins
before treatment	10.91 ± 1.94	10.82 ± 2.21	11.34 ± 1.69	10.04 ± 1.92	10.76 ± 1.64
after treatment	10.88 ± 1.75	10.60 ± 2.12	14.08 ± 2.26^**^††	14.52 ± 2.98^*^††	17.01 ± 3.35^*^†
BP, cmH₂O
before treatment	5.71 ± 1.24	5.65 ± 1.91	5.71 ± 1.59	6.12 ± 1.64	6.51 ± 2.23
after treatment	5.89 ± 1.55	5.64 ± 1.89	5.67 ± 1.54	6.09 ± 1.58	6.51 ± 2.17
PT, cmH₂O
before treatment	7.58 ± 1.09	7.68 ± 1.11	7.99 ± 0.65	7.51 ± 1.22	8.11 ± 1.33
after treatment	7.55 ± 1.06	7.71 ± 1.04	8.34 ± 0.65	12.43 ± 1.03^*^†	16.94 ± 2.41^*^†
MVP, cmH₂O
before treatment	24.6 ± 2.10	27.0 ± 3.00	25.1 ± 2.24	26.8 ± 1.38	26.6 ± 2.45
after treatment	24.4 ± 1.03	26.8 ± 2.61	26.4 ± 2.38	30.7 ± 1.58^*^†	36.3 ± 2.20^*^†
PVR, ml
before treatment	0.11 ± 0.02	0.12 ± 0.01	0.11 ± 0.02	0.11 ± 0.02	0.09 ± 0.03
after treatment	0.11 ± 0.01	0.11 ± 0.02	0.10 ± 0.03	0.11 ± 0.02	0.10 ± 0.04

^*

P <0.01,

^**

P <0.05 (paired t-test);

^†

P <0.01,

^††

P<0.05 vs vehicle injection (Dunnett’s multiple comparison test)