Table 2.
Comparisons of patients with FXIa and TF activity (+) with those without such activity (0) on admission
| Variable | TF 0 | TF + | p | FXIa 0 | FXIa + | p |
|---|---|---|---|---|---|---|
| N=143 | N=58 | N=73 | N=132 | |||
| Age, y | 56 (44–66) | 58.5 (45–67.5) | 0.47 | 57 (48–70) | 56 (44.2–64) | 0.16 |
| Male, n(%) | 91 (63.6) | 27 (46.6) | 0.03 | 50 (68.5) | 71 (53.8) | 0.04 |
| BMI, kg/m2 | 27.2 (3.8) | 27.1 (3.4) | 0.61 | 27.2 (3.9) | 27.1 (3.6) | 0.86 |
| Smoking, n(%) | 48 (33.6) | 13 (22.4) | 0.12 | 28 (38.4) | 34 (25.8) | 0.06 |
| Hypertension, n(%) | 92 (64.3) | 46 (79.3) | 0.04 | 54 (74) | 86 (65.2) | 0.19 |
| Diabetes, n(%) | 26(18.2) | 13 (22.4) | 0.48 | 0 (0) | 39 (29.5) | <0.01 |
| Previous MI, n(%) | 43 (30.1) | 19 (32.8) | 0.71 | 17 (23.3) | 46 (34.8) | 0.15 |
| Previous stroke, n(%) | 25 (17.5) | 14 (24.1) | 0.28 | 10 (13.7) | 29 (22) | 0.15 |
| medication | ||||||
| statins, n(%) | 93 (65.5) | 42 (72.4) | 0.34 | 47 (64.4) | 91 (69.5) | 0.46 |
| β-blockers, n(%) | 79 (55.2) | 33 (56.9) | 0.83 | 36 (49.3) | 77 (58.3) | 0.21 |
| ACEIs, n(%) | 101 (70.6) | 42 (72.4) | 0.8 | 53 (72.6) | 92 (69.7) | 0.66 |
| aspirin, n(%) | 123 (86) | 53 (91.4) | 0.29 | 61 (83.6) | 119 (90.2) | 0.17 |
| Laboratory tests | ||||||
| creatinine, µmol/l | 79.6 (69–89.6) | 79 (69.9–87.9) | 0.53 | 79.8 (67.7–94.8) | 79 (70.7–88.4) | 0.43 |
| glucose, mmol/l | 5.3 (4.6–5.3) | 5.3 (4.7–5.3) | 0.98 | 5.3 (4.6–6.6) | 5.3 (4.6–6.2) | 0.89 |
| CRP, mg/l | 3 (1.8–4.8) | 3.3 (1.6–5.7) | 0.4 | 2.4 (1.7–.3) | 3.5 (1.9–5.5) | 0.001 |
| IL-6, pg/ml | 3.2 (2–5.1) | 3.9 (2.3–5.9) | 0.19 | 2.5 (1.9–4.3) | 4.1 (2.5–6) | 0.0001 |
| fibrinogen, g/l | 4.1±1.2 | 4.1±1.1 | 0.51 | 3.8±1.0 | 4.3±1.3 | 0.013 |
| total cholesterol, mmol/l | 5.1 (4.2–5.1) | 4.6 (4–4.6) | 0.31 | 5.1 (4.3–5.8) | 4.8 (4.2–5.6) | 0.31 |
| LDL-C, mmol/l | 3.1 (2.4–3.5) | 2.8 (2.3–3.3) | 0.33 | 2.9 (2.2–3.7) | 3 (2.4–3.4) | 0.73 |
| HDL-C, mmol/l | 1.2 (1–1.2) | 1.2 (1–1.2) | 0.47 | 1.2 (1–1.5) | 1.2 (1–1.5) | 0.36 |
| triglycerides, mmol/l | 1.3 (1–1.3) | 1.3 (1–1.3) | 0.96 | 1.3 (1.1–1.7) | 1.3 (1–1.8) | 0.35 |
| etiology | ||||||
| cryptogenic | 43 (30.1) | 19 (22.8) | 0.52 | 29 (29.7) | 34 (24.8) | 0.024 |
| atherothrombotic | 26 (18.2) | 10 (17.2) | 0.88 | 12 (16.4) | 25 (18.9) | 0.66 |
| cardioembolic | 16 (11.2) | 10 (17.2) | 0.25 | 7 (9.6) | 20 (15.2) | 0.26 |
| small vessel disease | 43 (30.1) | 10 (17.2) | 0.06 | 21 (28.8) | 33 (25) | 0.56 |
| other causes | 15 (10.5) | 9 (15.5) | 0.32 | 4 (5.5) | 20 (15.2) | 0.04 |
| scales | ||||||
| NIHSS1 | 5 (3–11) | 6.5 (3–12.3) | 0.51 | 5 (3–9) | 6 (3–13) | 0.3 |
| NIHSS 2 | 2 (0–5) | 3 (1–9) | 0.052 | 2 (0–4) | 3 (1–8) | 0.038 |
| Barthel index 2 | 95 (55–100) | 85 (44–100) | 0.13 | 100 (65–100) | 85 (45–100) | 0.023 |
| mRS 2 | 1.9±1.9 | 2.5±2 | 0.07 | 1 (0–3) | 1.5 (1–4) | 0.037 |
Values are given as mean±SD, median (interquartile range), or percentage. Plasma TF levels were unavailable in 4 acute stroke patients.
Abbreviations see Table 1.