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. Author manuscript; available in PMC: 2012 Sep 21.
Published in final edited form as: Brain Res. 2011 Jul 12;1413:9–23. doi: 10.1016/j.brainres.2011.06.066

Figure 4.

Figure 4

The microinjection into the LDT-PPT of an antisense oligodeoxynucleotide (OD) directed against NGF cat mRNA produces changes in sleep and wakefulness. The charts in A illustrate the relative time spent in each behavioral state during daily recording sessions without injections (baseline), with control OD injections (control OD) and antisense OD injections (antisense). This cat received a series of five control and antisense OD injections that were delivered in consecutive days (marked by the bars in the abscissa in the upper and lower charts in A). The control and antisense OD series were separated by 25 days. Hypnograms taken from a representative baseline session and from the third day of control and antisense OD injections depict the alterations in sleep and wakefulness cycle that typically occurred during antisense OD sessions (B).