Splenic CD4+CD25− Teff were purified from littermate or T-PPAR mice by magnetic bead purification. 0.75–1 × 106 Teff/mouse were injected i.p. into RAG-1−/− mice. A) Mice were weighed once per week. Mean of weekly weights are shown as % of mean starting weights. Littermate, (n=14); T-PPAR, (n=13). B) Typical examples of colon histology at 7 weeks. C) Compilation and means of histological colitis scores. Error bars shown as s.e.m. Littermates (n=8), T-PPAR (n=8). *, p value <0.05; ***, p value <0.001.