Table 2. HLA typing and timing of transplantation.
Phase | At diagnosis | Transplant during TKI | Comments |
---|---|---|---|
CP | Consider HLA typing if high risk Sokal | If IM failure first line, then failure of 2nd generation TKI If IM failure first line, and T315I mutation present |
Consider transplant if patients young and have HLA matched sibling |
AP, BC | HLA typing for all | Transplant all patients | Give TKI until HLA matched sib or URD found, then transplant |