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. Author manuscript; available in PMC: 2011 Oct 9.

Published in final edited form as: J Viral Hepat. 2009 Jul 28;17(3):208–216. doi: 10.1111/j.1365-2893.2009.01169.x

The distribution of amino acid substitutions across the NS5A region in the period between week 4 and week 12 in SVR (Panel A), BT (Panel B) and NR (Panel C) patients. Each line represents one patient, with vertical lines indicating amino acid substitutions between weeks 4 and 12. Most substitutions occurred in the carboxyl terminal region around V3. There were more amino acid substitutions overall in the SVR and BT patients than were observed in the NR patients. Six NR patients, listed as 7–12, demonstrated no mutations whatsoever in this region.

The distribution of amino acid substitutions across the NS5A region in the period between week 4 and week 12 in SVR (Panel A), BT (Panel B) and NR (Panel C) patients. Each line represents one patient, with vertical lines indicating amino acid substitutions between weeks 4 and 12. Most substitutions occurred in the carboxyl terminal region around V3. There were more amino acid substitutions overall in the SVR and BT patients than were observed in the NR patients. Six NR patients, listed as 7–12, demonstrated no mutations whatsoever in this region.